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Stacking two appetite-active compounds can amplify them, which is the single biggest tolerability concern with any cagrilintide-plus-tirzepatide concept

EverydayHealth:

A phase II trial of Paclitaxel plus biweekly cetuximab for patients with recurrent or metastatic head and neck cancer previously treated with both platinum-based chemotherapy and anti-PD-1 antibody

Therefore, although substance P is expected to induce antitumor immune responses, it can also promote tumor metastasis, at least in mouse models of breast tumors